MICROGLIA RAGE EXACERBATES THE PROGRESSION OF NEURODEGENERATION WITHIN THE SOD1 G93A MURINE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS IN A SEX-DEPENDENT MANNER

Abstract Background Burgeoning evidence highlights seminal roles for microglia in the pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS).The receptor for advanced glycation end products (RAGE) binds ligands relevant to ALS that accumulate in the diseased spinal cord and RAGE has been previously implicated in th

Increasing irrigation efficiency is often assumed to be a means of saving water and a route to increasing Still Life Art irrigated agricultural production or making water available for other purposes, such as communities, industry or ecosystems.There is a growing body of literature arguing that increasing irrigation efficiency does not reduce consu

An unsteady flow formation in Couette motion of an electrically conducting fluid subject to transverse magnetic field has been analyzed in the presence of suction/injection through the porous plates when one of the porous plates is in ramped motion.It is assumed that the porous plates are uniformly permeable and the fluid SILK PROTEIN is entering t

The study aimed to investigate the impact of posterior element and ligament removal on the maximum von Mises stress, and maximum shear stress of the eight-layer annulus for treating stenosis at the L3-L4 and L4-L5 levels in the lumbar spine.Previous studies have indicated that laminectomy alone can result in segmental instability unless fusion is p

Agriculture plays a pivotal role in Africa, contributing significantly to sustainable Brain Teaser Puzzles farming practices and the establishment of resilient food systems.Within this context, the use of various types of biostimulants, including microbial biostimulants such as Plant Growth-Promoting microorganisms (PGPM) and non-microbial products